The Laboratory of Laser Molecular Imaging and Machine Learning was created under a grant by the decree of the Government of the Russian Federation No. 220. Project “Development of methods for screening non-invasive diagnostics of viral and bacterial respiratory infections using laser spectroscopy and artificial intelligence methods”
The laboratory is an analytical center equipped with a set of scientific equipment for laser spectroscopy, specialized software that implements machine and deep learning in the field of creating predictive models for the classification of laser spectroscopy data.
For this, the original laser gas analyzer is being modernized, combining optical-acoustic detection and a laser source based on optical parametric oscillation.
A complex is being developed for Raman spectroscopy in the terahertz and IR ranges, including in the regime of giant and locally enhanced Raman spectroscopy.
An approach is being developed based on machine learning and spectral taxonomy methods, super-resolution reconstruction methods, deep neural networks to the content analysis of spectra of multicomponent samples based on spectral patterns and a priori information about the spectral characteristics of individual components, and the development of predictive models for subsequent classification.
Methods for screening non-invasive diagnostics of viral and bacterial respiratory infections based on spectral analysis are being developed:
- exhaled air using laser optical-acoustic spectroscopy and artificial intelligence (AI) methods;
- biological fluids using laser Raman spectroscopy and AI methods.
A provocative test is being developed to assess the presence of viral respiratory infections on the mucous membrane of the oral cavity and broncho-pulmonary system using laser spectroscopy.
The laboratory is equipped with modern equipment allowing to conduct world-class research:
The inVia Reflex system for Raman spectral analysis is one of the main tools to be used in this project. It has unique capabilities for recording Raman spectra in the THz-IR ranges.
Molecular spectroscopy analysis workstation with Intel Xeon Platinum CPU and GPU.
2P Microendoscope for MPTflex multiphoton microscope. Allows for in-vivo interstitial imaging, fluorophore study.
Vibration decoupled optical table – for positioning vibration-sensitive equipment, in particular samples for SERS.
The system for automatic sampling and thermal desorption with a set of auxiliary equipment will be used for the pre-concentration of gas samples.
Fiber laser Raman spectrometer i-Raman Plus or similar – for in-vivo examination of the oral mucosa.
Handheld scanner for OCT – for studying the process of optical clearing of biological tissues in-vivo.